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Bioorganometallic Chemistry – Synthesis and Antitumor Activity of Cobalt Carbonyl Complexes
Author(s) -
Jung Manfred,
Kerr David E.,
Senter Peter D.
Publication year - 1997
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19973300604
Subject(s) - cobalt , alkyne , chemistry , ligand (biochemistry) , biological activity , organometallic chemistry , group 2 organometallic chemistry , combinatorial chemistry , stereochemistry , chemical synthesis , in vitro , organic chemistry , biochemistry , catalysis , receptor , molecule
The interaction of organometallic compounds with biological systems, generally called bioorganometallic chemistry, is receiving increasing interest. We present the first part of our studies concerning the biological activity of organometallic compounds. Several alkyne‐cobalt carbonyl complexes inhibited the growth of human melanoma and lung carcinoma cell lines. They are more active than uncomplexed dicobalt octacarbonyl, cobalt chloride, or the free ligand. A significant difference in potency towards the lung carcinoma cell line was observed among the cobalt complexes, indicating that the complexed ligand may influence cytotoxic activity. These results suggest that further exploratory work with such cobalt‐alkyne complexes is warranted.