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Structure‐Activity Relationships of Sandalwood Odorants: Synthesis and Odour of Methyl‐β‐santalol
Author(s) -
Buchbauer Gerhard,
ZcchmeisterMachhart Friederike,
WeißGreilar Petra,
Wolschann Peter
Publication year - 1997
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19973300407
Subject(s) - sandalwood , chemistry , stereochemistry , methyl group , molecule , chemical synthesis , group (periodic table) , traditional medicine , organic chemistry , biochemistry , in vitro , medicine
The synthesis and odour properties of the new santalol analogue, methyl‐β‐santalol, are described. The additional methyl group adjacent to the hydroxyl function of the standard molecule, β‐santalol, deprives the new compound of the sandalwood note. The synthesis and the odour evaluation of this compound supports the proposed model for sandalwood fragrance as it shows that the methyl group located at the osmophoric center prevents association of the molecule with the hypothetical receptor.