Antimalarial Activity of 1,4‐Epidioxy‐bisabola‐2,12‐diene Derivatives | Zendy

Rücker Gerhard | Zendy; Breitmaier Eberhard | Zendy; Manns Detlef | Zendy; Maier Walter | Zendy; Marek Anne | Zendy; Heinzmann Berta | Zendy; Heiden Klemens | Zendy; Seggewies Stephan | Zendy

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Antimalarial Activity of 1,4‐Epidioxy‐bisabola‐2,12‐diene Derivatives

Author(s) -

Rücker Gerhard,

Breitmaier Eberhard,

Manns Detlef,

Maier Walter,

Marek Anne,

Heinzmann Berta,

Heiden Klemens,

Seggewies Stephan

Publication year - 1997

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19973300104

Subject(s) - diene , in vivo , chemistry , biological activity , bicyclic molecule , chemical synthesis , stereochemistry , in vitro , organic chemistry , biochemistry , biology , natural rubber , microbiology and biotechnology

1,4‐Epidioxy‐bisabola‐2,12‐diene ( 3 ) and aromatic hydroperoxides ( 4, 5 ) were prepared by photoxidation of γ‐curcumene ( 1 ). Reduction and esterification of 6 and 7 afforded compounds 9 to 10 . All compounds were tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3 . The most active compounds, 3 and 9 , did not show in vivo antimalarial activity in mice.

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