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Antimalarial Activity of 1,4‐Epidioxy‐bisabola‐2,12‐diene Derivatives
Author(s) -
Rücker Gerhard,
Breitmaier Eberhard,
Manns Detlef,
Maier Walter,
Marek Anne,
Heinzmann Berta,
Heiden Klemens,
Seggewies Stephan
Publication year - 1997
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19973300104
Subject(s) - diene , in vivo , chemistry , biological activity , bicyclic molecule , chemical synthesis , stereochemistry , in vitro , organic chemistry , biochemistry , biology , natural rubber , microbiology and biotechnology
1,4‐Epidioxy‐bisabola‐2,12‐diene ( 3 ) and aromatic hydroperoxides ( 4, 5 ) were prepared by photoxidation of γ‐curcumene ( 1 ). Reduction and esterification of 6 and 7 afforded compounds 9 to 10 . All compounds were tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3 . The most active compounds, 3 and 9 , did not show in vivo antimalarial activity in mice.