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Dibenz[ b,f ]azepines, Part 7 [1] : Synthesis of New, Potentially CNS Active Dibenz[ b,f ]azepine Derivatives
Author(s) -
Haász Ferenc,
Tóth Zoltán,
Galamb Vilmos
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963291207
Subject(s) - azepine , chemistry , glyoxylic acid , acetic acid , stereochemistry , hemiacetal , medicinal chemistry , organic chemistry
Reactions of 5‐carboxamido‐5 H ‐dibenz[ b,f ]azepines ( 1a–1d ) with glyoxylic acid methylester methyl hemiacetal (GMHA) led to 5‐(carboxamido‐ N ‐α‐hydroxy‐acetic acid methyl ester)‐5 H ‐dibenz[ b,f ]azepines ( 2a–2d ). The reactions with glycols yielded the oligoethylene glycol derivatives ( 3,4 ). The new compounds were screened as anticonvulsants and/or antidepressants (AD).
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