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Chemistry of Indoles Carrying a Basic Function, Part 3 1 Synthesis of Spiro[cyclopropane‐1,3′[3 H ]indol]‐2′(1′ H )‐ones with Antihypoxic Effects
Author(s) -
Moldvai István,
GácsBaitz Eszter,
Balázs Mihály,
Incze Mária,
Szántay Csaba
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963291206
Subject(s) - cyclopropane , chemistry , dimer , dehydration , chemical synthesis , stereochemistry , medicinal chemistry , organic chemistry , ring (chemistry) , biochemistry , in vitro
Hydroxyindolones ( 1–6, 15–16 ) were transformed into isatinylidenes ( 7,9–13, 17–19 ) by dehydration with 4‐toluenesulfonic acid. The dimer‐type compounds ( 14, 20 ) were also isolated in a few cases. The obtained isatinylidenes were transformed into 3‐spiro‐cyclopropane‐oxindoles ( 21–32 ) with dimethyloxosulfonium methylide. Compound 22 shows protective effects against hypobaric hypoxia and triethyltin induced brain edema.