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Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1: 6‐Methyl Derivatives
Author(s) -
Aitkena R. Alan,
Bibby Michael C.,
Double John A.,
Phillips Roger M.,
Sharma Shiv Kumar
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963291104
Subject(s) - in vivo , chemistry , acetic acid , in vitro , substituent , stereochemistry , cell culture , biochemistry , biology , genetics , microbiology and biotechnology
A range of 17 derivatives of flavone‐8‐acetic acid (FAA) with a 6‐methyl substituent have been prepared and their anti‐tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro , this essentially disappears in vivo , possibly due to degradation before the compounds can reach the tumour site.