Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1: 6‐Methyl Derivatives | Zendy

Aitkena R. Alan | Zendy; Bibby Michael C. | Zendy; Double John A. | Zendy; Phillips Roger M. | Zendy; Sharma Shiv Kumar | Zendy

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Synthesis and Antitumour Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 1: 6‐Methyl Derivatives

Author(s) -

Aitkena R. Alan,

Bibby Michael C.,

Double John A.,

Phillips Roger M.,

Sharma Shiv Kumar

Publication year - 1996

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19963291104

Subject(s) - in vivo , chemistry , acetic acid , in vitro , substituent , stereochemistry , cell culture , biochemistry , biology , genetics , microbiology and biotechnology

A range of 17 derivatives of flavone‐8‐acetic acid (FAA) with a 6‐methyl substituent have been prepared and their anti‐tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro , this essentially disappears in vivo , possibly due to degradation before the compounds can reach the tumour site.

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