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Synthesis and Antibacterial Activity of 1‐β‐Methylcarbapenem Having a 1,3‐Diazabicyclo[3.3.0]octan‐4‐one Moiety
Author(s) -
Nam Ki Hong,
Oh ChangHyun,
Cho Jin Koo,
Kim Hyo Jung,
Lee KiSoo,
Cho JungHyuck
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963291004
Subject(s) - moiety , bicyclic molecule , substituent , chemistry , antibacterial activity , stereochemistry , ring (chemistry) , bacteria , antibacterial agent , lactam , organic chemistry , antibiotics , biochemistry , biology , genetics
The synthesis of new series of 1‐β‐methylcarbapenems having a 1,3‐diazabicyclo[3.3.0]octan‐4‐one moiety is described. Their in vitro antibacterial activities against both Gram‐positive and Gram negative bacteria are reported and the effect of the substituent on the bicyclic ring was investigated and was in agreement with findings from our previous studies.