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Research on Antifungal and Antimycobacterial Agents. Synthesis and Activity of 4‐Alkylthiopyridine‐2‐carbothioamides
Author(s) -
Klimešová Vera,
Svoboda Martin,
Waisser Karel,
Machácek Miloš,
Buchta Vladimír,
Odlerová Želmíra
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963291003
Subject(s) - antimycobacterial , candida krusei , candida glabrata , candida albicans , microbiology and biotechnology , aspergillus fumigatus , candida tropicalis , chemistry , trichophyton , mycobacterium fortuitum , mycobacterium tuberculosis , mycobacterium , biology , antifungal , medicine , tuberculosis , pathology
A series of 4‐alkylthiopyridine‐2‐carbothioamides have been prepared and evaluated in vitro for antimicrobial activity. Chemical structures have been demonstrated by IR and 1 H NMR data and by elemental analysis. The antimycobacterial activity of these compounds against Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium , and Mycobacterium fortuitum , and the antifungal activity against Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Trichosporon beigelii, Trichophyton mentagrophytes, Aspergillus fumigatus , and Absidia corymbifera were determined by the MIC values. Compounds 3 exhibit good antimycobacterial activity compared to isoniazide. A moderate antifungal activity was observed against T. mentagrophytes. Activity is influenced by hydrophobicity of the alkyl group.