Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3 H ‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7 H ‐1,2,4‐triazolo[3,4‐ b ][1,3,4]thiadiazines | Zendy

Ergenç Nedime | Zendy; Ulusoy Nuray | Zendy; Çapan Gültaze | Zendy; Sanis Gülten Ötük | Zendy; Kiraz Muammer | Zendy

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Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3 H ‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7 H ‐1,2,4‐triazolo[3,4‐ b ][1,3,4]thiadiazines

Author(s) -

Ergenç Nedime,

Ulusoy Nuray,

Çapan Gültaze,

Sanis Gülten Ötük,

Kiraz Muammer

Publication year - 1996

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19963290811

Subject(s) - chemistry , antimicrobial , staphylococcus epidermidis , stereochemistry , aryl , antifungal , 1,2,4 triazole , staphylococcus aureus , medicinal chemistry , organic chemistry , bacteria , microbiology and biotechnology , biology , alkyl , genetics

A series of 4‐(alkylidene/arylidene)amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3 H ‐1,2,4‐triazole‐3‐thiones ( 2 ) and 6‐aryl‐3‐(2‐furanyl)‐7 H ‐1,2,4‐triazolo[3,4‐ b ][1,3,4] thiadiazines ( 3 ) were synthesized. The configuration of 2g was assigned on the basis of 1 H‐NMR data. Of the new derivatives tested, only 2b, 2g , and 4f were found to be active against Staphylococcus aureus and/or Staphylococcus epidermidis (MIC 125–1.95 μg/ml), whereas all exhibited varying degrees of antifungal activity (MIC 25–0.8 μg/ml).

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