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Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3 H ‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7 H ‐1,2,4‐triazolo[3,4‐ b ][1,3,4]thiadiazines
Author(s) -
Ergenç Nedime,
Ulusoy Nuray,
Çapan Gültaze,
Sanis Gülten Ötük,
Kiraz Muammer
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963290811
Subject(s) - chemistry , antimicrobial , staphylococcus epidermidis , stereochemistry , aryl , antifungal , 1,2,4 triazole , staphylococcus aureus , medicinal chemistry , organic chemistry , bacteria , microbiology and biotechnology , biology , alkyl , genetics
A series of 4‐(alkylidene/arylidene)amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3 H ‐1,2,4‐triazole‐3‐thiones ( 2 ) and 6‐aryl‐3‐(2‐furanyl)‐7 H ‐1,2,4‐triazolo[3,4‐ b ][1,3,4] thiadiazines ( 3 ) were synthesized. The configuration of 2g was assigned on the basis of 1 H‐NMR data. Of the new derivatives tested, only 2b, 2g , and 4f were found to be active against Staphylococcus aureus and/or Staphylococcus epidermidis (MIC 125–1.95 μg/ml), whereas all exhibited varying degrees of antifungal activity (MIC 25–0.8 μg/ml).