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Pyridazines 79 [1] Novel Oxazolo[3′,2′:1,2]pyrrolo[3,4‐ d ]pyridazines and Imidazolo[1′,2′:1,2]pyrrolo[3,4‐ d ]pyridazines: Synthesis and Biological Evaluation
Author(s) -
Barth Birgit,
Dierich Manfred,
Heinisch Gottfried,
Matuszczak Barbara,
Mereiter Kurt,
Soder Josef,
Stoiber Heribert
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963290806
Subject(s) - pyridazine , tricyclic , chemistry , stereochemistry , reverse transcriptase inhibitor , reverse transcriptase , rna , biochemistry , gene
Starting from conveniently accessible ethyl 5‐aroyl‐4‐pyridazine‐carboxylates 6 representatives of the novel tricyclic systems 2 (with X = O and X = NH) were synthesised and screened as potential non‐nucleoside HIV‐1 reverse transcriptase inhibitors.
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