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Synthesis and Antidepressant Evaluation of New Hetero[2,1]benzothiazepine Derivatives
Author(s) -
Díaz Juan A.,
Vega Salvador,
Expósito María A.,
Mateo Candelaria C. Sánchez,
Darias Victoriano
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963290705
Subject(s) - antidepressant , pharmacology , chemistry , stereochemistry , medicine , psychiatry , anxiety
As a part of a research program directed to the discovery of novel antidepressant agents, a series of new hetero[2,1]benzothiazepine derivatives was synthesized. Some of these compounds antagonized the ptosis and motor depression induced by tetrabenazine and were also active in the Porsolt forced swimming test.