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Stability of Suramin in Aqueous Solution; Possible Implications for the Search for Suramin Metabolites in Patients
Author(s) -
Kassack Matthias,
Nickel Peter
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963290502
Subject(s) - suramin , aqueous solution , chemistry , pharmacology , chromatography , biochemistry , biology , organic chemistry , in vitro
The stability of an aqueous solution of suramin has been determined. The only degradation product detectable by HPLC was the amine precursor 2. The decomposition kinetics of suramin at different temperatures are shown. Because of first order kinetics the Arrhenius equation could be used to evaluate the decomposition data. A good correlation was obtained between the reaction constants and the temperature ( r = 0.9898). After 42 days at 37 °C, 2% of suramin are hydrolysed. Possible implications of our results for the search for suramin metabolites in patients are discussed.