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New NO‐Donors with Antithrombotic and Vasodilating Activities, Part 15 Nitrolic Acids
Author(s) -
Rehse Klaus,
Herpel Martin,
Piechocki Daniela
Publication year - 1996
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19963290205
Subject(s) - antithrombotic , chemistry , thrombus , vasodilation , pharmacology , blood pressure , oral administration , nitric oxide , acetic acid , biochemistry , medicine , organic chemistry
Five 1‐oximino‐1‐nitro compounds (nitrolic acids) were prepared and tested for antithrombotic and blood pressure lowering activities. 1‐Nitro‐ethanone 1‐oxime ( 1 , ethylnitrolic acid) 2 h after oral administration to rats inhibited thrombus formation by a laser beam in mesenteric arterioles of rats by 69% and by 46% in venules (60 mg/kg). The blood pressure of SHR rats even at this high dose only was decreased by 10% suggesting that antithrombotic and blood pressure effects can be dissociated. The in vitro decomposition of 1 at 37 °C nearly exclusively gave N 2 O and acetic acid indicating that HNO primarily had been formed.