New NO‐Donors with Antithrombotic and Vasodilating Activities, Part 15 Nitrolic Acids

Five 1‐oximino‐1‐nitro compounds (nitrolic acids) were prepared and tested for antithrombotic and blood pressure lowering activities. 1‐Nitro‐ethanone 1‐oxime ( 1 , ethylnitrolic acid) 2 h after oral administration to rats inhibited thrombus formation by a laser beam in mesenteric arterioles of rats by 69% and by 46% in venules (60 mg/kg). The blood pressure of SHR rats even at this high dose only was decreased by 10% suggesting that antithrombotic and blood pressure effects can be dissociated. The in vitro decomposition of 1 at 37 °C nearly exclusively gave N 2 O and acetic acid indicating that HNO primarily had been formed.