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An Improved and Large Scale Synthesis of the Natural Coumarin Scopoletin
Author(s) -
Hauer Hermann,
Ritter Thomas,
Grotemeier Gregor
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953281009
Subject(s) - scopoletin , coumarin , chemistry , organic chemistry , magnesium , combinatorial chemistry , medicine , alternative medicine , pathology
Isovanillin was oxidized with magnesium monoperoxyphthalate to 4‐methoxyresorcinol ( 2 ) and the latter was reacted with 3‐oxopropionic acid ethylester prepared in situ to give scopoletin ( 1 ). These reactions can be achieved in kg scale in high yields.