Chemotactic Peptide Analogues. Synthesis and Chemotactic Activity of  N ‐Formyl‐Met‐Leu‐Phe Analogues Containing ( S )‐Phenylalaninol Derivatives | Zendy

Zecchini Giampiero Pagani | Zendy; Paradisi Mario Paglialunga | Zendy; Torrini Ines | Zendy; Spisani Susanna | Zendy

Premium

Chemotactic Peptide Analogues. Synthesis and Chemotactic Activity of N ‐Formyl‐Met‐Leu‐Phe Analogues Containing ( S )‐Phenylalaninol Derivatives

Author(s) -

Zecchini Giampiero Pagani,

Paradisi Mario Paglialunga,

Torrini Ines,

Spisani Susanna

Publication year - 1995

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19953280908

Subject(s) - chemotaxis , chemistry , biological activity , superoxide , chemical synthesis , peptide , formyl peptide receptor , lysozyme , stereochemistry , peptide synthesis , oligopeptide , phenylalanine , biochemistry , receptor , in vitro , enzyme , amino acid

The synthesis and the biological activity towards human neutrophils of some N ‐formyl‐Met‐Leu‐Phe‐OMe analogues containing ( S )‐phenylalaninol (Pheol) or its derivatives in place of the native phenylalanine are reported. While the analogue containing Pheol ( 4 ) was found to be devoid of significant biological activity, its esters 3 and 5 , although inactive as chemoattractants, are able to strongly stimulate superoxide production and are active with a lower efficacy in the lysozyme release.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research