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Antifungal Agents, Part 11: Biphenyl Analogues of Naftifine: Synthesis and Antifungal Activities
Author(s) -
Porretta Giulio Cesare,
Fioravanti Rossella,
Biava Mariangela,
Artico Marino,
Villa Adelaide,
Simonetti Nicola
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280907
Subject(s) - antifungal , biphenyl , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , microbiology and biotechnology , biology
A series of naftifine analogues having the biphenyl instead of the naphthyl moiety have been synthesized in a search devoted to study bioanalogues of clinically efficacious antifungal agents. The new derivatives were tested against Candida albicans by the direct contact method. They were also assayed against Gram‐positive and Gram‐negative bacteria and against some isolates of plant pathogenic fungi. Derivatives 8a, 8c , and 9a were found to be active against Candida albicans , derivative 5a was active against E. coli , a very resistant species to antimycotic agents, and derivatives 8a and 8b inhibited the plant pathogenic Rhizoctonia solani .