Structure‐Activity Relationships in a Series of 8‐Substituted Xanthines as Bronchodilator and A 1 ‐Adenosine Receptor Antagonists | Zendy

Corsano Stefano | Zendy; Strappaghetti Giovannella | Zendy; Scapicchi Rossana | Zendy; Lucacchini Antonio | Zendy; Senatore Generoso | Zendy

Premium

Structure‐Activity Relationships in a Series of 8‐Substituted Xanthines as Bronchodilator and A 1 ‐Adenosine Receptor Antagonists

Author(s) -

Corsano Stefano,

Strappaghetti Giovannella,

Scapicchi Rossana,

Lucacchini Antonio,

Senatore Generoso

Publication year - 1995

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19953280905

Subject(s) - theophylline , xanthine , chemistry , bronchodilator , piperazine , adenosine , adenosine receptor , adenosine a1 receptor , stereochemistry , agonist , pharmacology , receptor , biochemistry , medicine , enzyme , organic chemistry , biology , asthma

Four new derivatives of 8‐piperazine ethyl xanthine were synthesized and their bronchospasmolytic activity and A 1 ‐adenosine affinity were studied. Their relaxant action in the tracheal muscle was lower than that of theophylline and that of theophylline derivatives substituted at the 7‐position. Only compound 9 , where the methyl group in the 1‐position of the theophylline was substituted by an isobutyl group, shows a good affinity towards the A 1 ‐adenosine receptor.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research