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The Structure—Activity Relationship of a New Anti‐Arrhythmic Agent 1‐[2‐Acetoxy‐3‐(4‐phenyl‐1‐piperazinyl)propyl]pyrrolidin‐2‐one
Author(s) -
Malawska Barbara,
Filipek Barbara,
Stadnicka Katarzyna,
CiechanowiczRutkowska Maria
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280613
Subject(s) - chemistry , stereochemistry , structure–activity relationship , crystal structure , crystallography , in vitro , biochemistry
This paper reports the synthesis of the new compound 1‐[2‐acetoxy‐3‐(4‐phenyl‐1‐piperazinyl)propyl]pyrrolidin‐2‐one (Ac‐MG‐1). Preliminary pharmacological assessment revealed that Ac‐MG‐1 possesses anti‐arrhythmic activity and a local anesthetic effect. The crystal structure of Ac‐MG‐1 was determined by X‐ray diffraction, and conformational analysis was performed both for Ac‐MG‐1 and for other derivatives of (arylpiperazinyl)propylpyrrolidin‐2‐one.