The Structure—Activity Relationship of a New Anti‐Arrhythmic Agent 1‐[2‐Acetoxy‐3‐(4‐phenyl‐1‐piperazinyl)propyl]pyrrolidin‐2‐one

This paper reports the synthesis of the new compound 1‐[2‐acetoxy‐3‐(4‐phenyl‐1‐piperazinyl)propyl]pyrrolidin‐2‐one (Ac‐MG‐1). Preliminary pharmacological assessment revealed that Ac‐MG‐1 possesses anti‐arrhythmic activity and a local anesthetic effect. The crystal structure of Ac‐MG‐1 was determined by X‐ray diffraction, and conformational analysis was performed both for Ac‐MG‐1 and for other derivatives of (arylpiperazinyl)propylpyrrolidin‐2‐one.