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Platelet Antiaggregant Methoxyphenylthienyl Ketoxime Ethers: Synthesis and Structure‐Activity Relationships
Author(s) -
VaracheLembège Martine,
Nuhrich Alain,
Renard Pierre,
Duboudin Françoise,
Vercauteren Joseph,
Devaux Guy
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280505
Subject(s) - chemistry , arachidonic acid , in vitro , platelet , stereochemistry , biological activity , aspirin , platelet aggregation , organic chemistry , biochemistry , enzyme , medicine
Some new oximinoalkanoic (n = 2,3,4) esters and acids derived from methoxyphenylthienyl ketones have been synthesized and evaluated in vitro for their inhibitory effects on arachidonic acid‐induced human platelet aggregation. Of the eighteen oximinoethers tested the most active derivatives, which were four times more active as aspirin, belonged to the para methoxy series with Z configuration and n = 2 or 3.