1,3‐Diphenylpropane‐1,3‐diamines, VI : DNA‐Interaction, Estrogen Receptor Affinity, and Cytostatic Activity of 1,3‐Diphenylpropane‐1,3‐diamine‐Pt(II) Complexes | Zendy

Kammermeier Thomas | Zendy; Wiegrebe Wolfgang | Zendy

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1,3‐Diphenylpropane‐1,3‐diamines, VI : DNA‐Interaction, Estrogen Receptor Affinity, and Cytostatic Activity of 1,3‐Diphenylpropane‐1,3‐diamine‐Pt(II) Complexes

Author(s) -

Kammermeier Thomas,

Wiegrebe Wolfgang

Publication year - 1995

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19953280504

Subject(s) - chemistry , diamine , estrogen , estrogen receptor , cytosol , dna , receptor , stereochemistry , medicinal chemistry , biochemistry , organic chemistry , medicine , endocrinology , biology , cancer , breast cancer , enzyme

The Pt(II) complexes of 1,3‐diphenyl propane ‐1,3‐diamines (part IV 2) ) were tested for DNA interaction (UV‐difference spectroscopy, Tables 1 and 2), for affinity to the estrogen receptor (calf uterus cytosol; scarcely any affinity), and for cytostatic activity at estrogen independent MDA‐MB 231 cells (Tables 3 and 4) and estrogen dependent MCF‐7 cells (Tables 5 and 6). The data are compared with those reported for the analogous 1,2‐dipheny lethane ‐1,2‐diamine‐Pt(II) complexes: most probably, the cytostatic activity is not mediated by the estrogen receptor.

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