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Biomimetische aromatische Hydroxylierung ausgewählter Diphenylmethanderivate
Author(s) -
Fröhlich Luela,
Pietzyk Birgit,
Göber B.
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280419
Subject(s) - hydroxylation , chemistry , diphenylmethane , anisole , catalysis , monooxygenase , cytochrome , naphthalene , organic chemistry , toluene , thioanisole , benzene , alkane , manganese , biocatalysis , cytochrome p450 , enzyme , reaction mechanism
Abstract Many oxidation systems using iron or manganese porphyrins as catalysts and various oxygen atom donors have been reported to mimic cytochrome P‐450‐dependent monooxygenases 1–3) . Such systems are very efficient for epoxidation of alkenes and reasonably for alkane hydroxylation. Few authors also reported about the activity to hydroxylate aromatic rings. In these cases low yields were found for hydroxylation of anisole, benzene, naphthalene, and toluene 4–7) . Biomimetic systems based on metalloporphyrin catalysts can be used for preparative oxidation of some substrates and appear particularly useful for the preparation of oxidized metabolites of drugs or other xenobiotics.