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Syntheses of ( RS )‐ and ( S )‐(−)‐Nazlinin and ( RS )‐ and (+)‐6‐Azacyclodeca[5,4‐ b ]indol‐1‐amine
Author(s) -
Mahboobi Siavosh,
Wagner Wolfgang,
Burgemeister Thomas
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280415
Subject(s) - amine gas treating , chemistry , stereochemistry , biogenic amine , medicinal chemistry , organic chemistry , biochemistry , receptor , neurotransmitter
( RS )‐1‐(4‐Aminobutyl)‐1,2,3,4‐tetrahydro‐β‐carboline (( RS )‐1) was synthesized in two different ways. The preparation of ( S )‐(−)‐1 was performed both by asymmetric reduction with ⩾ 95% ee and by synthesis from ( S )‐(+)‐3. From this compound also (+)‐6‐azacyclodeca[5,4‐ b ]indol‐1‐amine ((+)‐2) was prepared with high enantioselectivity.