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Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XXIX: Influence of the Antithrombotic Oligoamine RE 1492 on the Storage of Red Blood Cells, Morphology, their Potassium and ATP Content, Hemolysis and Viability
Author(s) -
Rehse Klaus,
Müller Susann
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280409
Subject(s) - echinocyte , chemistry , hemolysis , potassium , phospholipid , biophysics , platelet , biochemistry , red blood cell , membrane , biology , immunology , organic chemistry
The influence of RE 1492 on the storage of red blood cells (RBCs) was investigated. RE 1492 (c ⩾ 50 μmol/L) induces the formation of cup cells and hence delays the appearance of echinocytes and crenated spheres in the blood. A concentration of 50 μmol/L RE 1492 drops hemolysis by 50 %. At this concentration after 6 h of storage the potassium efflux was enhanced significantly. The ATP concentration was decreased between 12 h and 24 h of storage. During the first 6 h these alterations have no effect on the in vivo viability of RBCs. After 12 h of storage a significant reduction in viability is observed. We suppose that the changes observed are due to the intercalation of RE 1492 in the phospholipid matrix of the RBC membrane, followed by an accelerated substrate turnover in the RBCs.