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Pyridazines, LXXII: On the Synthesis of Azinium and Diazinium Compounds Structurally Related to Pyridazomycin
Author(s) -
Easmon Johnny,
Heinisch Gottfried,
Holzer Wolfgang,
Matuszczak Barbara
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280403
Subject(s) - pyridazine , moiety , chemistry , stereochemistry , antifungal , alkyl , pyrazine , pyridine , ring (chemistry) , carboxamide , chemical synthesis , side chain , in vitro , medicinal chemistry , organic chemistry , biochemistry , biology , microbiology and biotechnology , polymer
Preparation of series of pyridine‐, pyridazine‐, and pyrazine‐derived carboxamides bearing at the ring N ‐atom an alkyl side‐chain with a terminal carboxylic group ( 7 – 11 ) or with a terminal acetylamino malonic ester moiety ( 13–17, 19–23 ) is described. Two desaza‐pyridazomycin derivatives ( 24, 26 ) and homologs thereof ( 25, 27 ) were synthesised. The novel compounds which are structurally related to the antifungal antibiotic pyridazomycin were screened for antifungal activity: preliminary in vitro tests showed no activity.