Pyridazines, LXXII: On the Synthesis of Azinium and Diazinium Compounds Structurally Related to Pyridazomycin | Zendy

Easmon Johnny | Zendy; Heinisch Gottfried | Zendy; Holzer Wolfgang | Zendy; Matuszczak Barbara | Zendy

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Pyridazines, LXXII: On the Synthesis of Azinium and Diazinium Compounds Structurally Related to Pyridazomycin

Author(s) -

Easmon Johnny,

Heinisch Gottfried,

Holzer Wolfgang,

Matuszczak Barbara

Publication year - 1995

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19953280403

Subject(s) - pyridazine , moiety , chemistry , stereochemistry , antifungal , alkyl , pyrazine , pyridine , ring (chemistry) , carboxamide , chemical synthesis , side chain , in vitro , medicinal chemistry , organic chemistry , biochemistry , biology , microbiology and biotechnology , polymer

Preparation of series of pyridine‐, pyridazine‐, and pyrazine‐derived carboxamides bearing at the ring N ‐atom an alkyl side‐chain with a terminal carboxylic group ( 7 – 11 ) or with a terminal acetylamino malonic ester moiety ( 13–17, 19–23 ) is described. Two desaza‐pyridazomycin derivatives ( 24, 26 ) and homologs thereof ( 25, 27 ) were synthesised. The novel compounds which are structurally related to the antifungal antibiotic pyridazomycin were screened for antifungal activity: preliminary in vitro tests showed no activity.

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