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Investigations on the Amidine System in Amidinobenzisothiazole Derivatives
Author(s) -
Bacchi Alessia,
Carcelli Mauro,
Pelizzi Giancarlo,
Vicini Paola
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280303
Subject(s) - amidine , hydrochloride , chemistry , free base , nuclear magnetic resonance spectroscopy , stereochemistry , base (topology) , medicinal chemistry , organic chemistry , mathematics , salt (chemistry) , mathematical analysis
The amino/imino equilibrium is studied in free bases and hydrochloride salts of amidinobenzisothiazole derivatives by IR and 1 H‐NMR spectroscopy. The X‐ray crystallographic analysis of two of these compounds shows that the free base exists as amino form whereas the hydrochloride as imino form.