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Synthesis of the First Penicillin Derivatives with Medium‐Sized Lactam Ring and of Related Thiazolidines
Author(s) -
Imming Peter
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280302
Subject(s) - lactam , penicillin , ring (chemistry) , chemistry , succinic acid , adipic acid , beta lactam , stereochemistry , combinatorial chemistry , organic chemistry , antibiotics , biochemistry
The novel concept of penicillin derivatives 4 with a medium‐sized instead of a β‐lactam ring is presented. Two synthetic paths were invented, resulting in the evaluation of the synthetic potential in the succinic, glutaric, and adipic acid series. A number of novel penicillin‐derived thiazolidines were prepared, notably the derivatives 16 and 22 with anellated 7‐ and 13‐membered lactam ring.

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