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Some Analogues of 1,4‐Disubstituted Piperazines as Hypnotic and Sedative Agents
Author(s) -
Chilmonczyk Zdzisław,
Bogdal Maria,
Zaworska Alicja,
Cybulski Jacek,
Szelejewski Wiesław
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280218
Subject(s) - chemistry , hypnotic , hexobarbital , anticonvulsant , sedative , sedative/hypnotic , pharmacology , amphetamine , locomotor activity , biological activity , stereochemistry , organic chemistry , psychology , medicine , epilepsy , in vitro , biochemistry , psychiatry , dopamine , microsome , enzyme
Preparation, analytical data, and biological properties such as acute toxicity, influence on spontaneous and amphetamine induced locomotor activity, hypnotic activity, influence on hexobarbital narcosis and anticonvulsant activity of new analogues of pyrimidyl piperazines ‐ ethyl 3‐[4‐(2‐pyrimidyl)‐1‐piperazinyl]‐3‐oxopropanoate ( 4 ), 1‐[4‐(2‐pyrimidyl)‐1‐piperazinyl]‐1,3‐butandione ( 5 ), ethyl 3‐[4‐(2‐pyrimidyl)‐1‐piperazinyl]butanoate ( 6 ) and 1‐[4‐(2‐pyrimidyl)‐1‐piperazinyl]‐2‐acetyl‐1‐hexanone ( 7 ) ‐ are reported.