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Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XXVIII: Oligoamines with Fluorescent Properties. Part C: Fluorescent Oligoamines with Enhanced Hydrophilic Properties
Author(s) -
Rehse Klaus,
Seidel Torsten
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280208
Subject(s) - fluorescence , platelet aggregation , chemistry , anticoagulant , biophysics , platelet , biology , medicine , physics , quantum mechanics , immunology
Fifteen fluorescent oligoamines with one or two fluorescent groups and two or three basic N‐functions were prepared and tested for antiplatelet activity ( Born ‐test). Five compounds involving three different fluorophores, i.e. 2‐fluorenyl, 1‐pyrenyl, and 9‐phenanthryl, show an IC 50 of 7–11 μmol/L. They are suitable to serve as probes in the field of oligoamine‐biopolymere interactions.