Transdermal Absorption of Dimethindene in Man

Dimethindene and its metabolite N ‐demethyldimethindene were determined in human urine after dermal administration of dimethindene. The HPLC‐method used was previously described. Data of 8 volunteers are presented. After 32 h an average of 0.023% of the administered dose of dimethindene and 0.022% of N ‐demethyldimethindene were excreted into urine. Since also after oral administration of dimethindene only about 1% of unmetabolised dimethindene is found in urine it can be concluded that a certain amount of dimethindene is absorbed through the skin after dermal administration.