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(2 R ,4 S )‐2‐Aminomethyl‐5,5‐dimethyl‐1,3‐thiazolidine‐4‐carboxylic Acid Dihydrochloride: Synthesis, Epimerization, and Derivatives
Author(s) -
Imming Peter
Publication year - 1995
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19953280115
Subject(s) - chemistry , thiazolidine , epimer , aqueous solution , carboxylic acid , penicillamine , chemical synthesis , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry , in vitro
The preparation of the title compound 6a from penicillamine 5 or from penicillins 7 , the spectroscopic data and stereochemical assignments are given. 6a quickly epimerizes at C‐2 in dilute aqueous solution. Details are given along with the preparation of the new thiazolidines 10 – 13 from 6 .