Constituents of Tropical Medicinal Plants, LXIII: Synthesis of 2‐Methoxyonychine Alkaloids ‐ Structure Revision of Oxylopidine | Zendy

Achenbach Hans | Zendy; Schwinn Andreas | Zendy

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Constituents of Tropical Medicinal Plants, LXIII: Synthesis of 2‐Methoxyonychine Alkaloids ‐ Structure Revision of Oxylopidine

Author(s) -

Achenbach Hans,

Schwinn Andreas

Publication year - 1994

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19943271202

Subject(s) - crotonaldehyde , yield (engineering) , chemistry , condensation , organic chemistry , materials science , physics , metallurgy , thermodynamics , catalysis

Condensation of β‐aminocinnamic acid esters with 3‐chloro‐2‐methoxy‐crotonaldehyde opened an easy access to 2‐phenyl‐5‐methoxy‐4‐methylnicotinic acid esters which were cyclized by polyphosphoric acid to yield the corresponding 2‐methoxyonychines. By this method a number of 2‐methoxy‐substituted onychines were prepared for the first time, i.a. oxylopidine, the structure of which has to be revised.

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