Bronchodilator Activity of Theophylline Derivatives Substituted at the 7‐Position | Zendy

Corsano Stefano | Zendy; Scapicchi Rossana | Zendy; Strappaghetti Giovannella | Zendy

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Bronchodilator Activity of Theophylline Derivatives Substituted at the 7‐Position

Author(s) -

Corsano Stefano,

Scapicchi Rossana,

Strappaghetti Giovannella

Publication year - 1994

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19943271006

Subject(s) - theophylline , bronchodilator , chemistry , piperazine , pharmacology , stereochemistry , ring (chemistry) , medicine , organic chemistry , asthma

Theophylline derivatives with several groups linked at the 7‐position were synthesized and their pharmacological activities were studied on guinea pig. Relaxant action in the tracheal muscle was increased in comparison with that of theophylline when the 3(2 H )‐pyridazinone system was linked to 7‐(2‐ethyl)‐theophylline through the piperazine ring, but decreased when the 7‐(2‐ethyl)‐theophylline was linked to 3(2 H )‐pyridazinone ring through an amino group.

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