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Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XXIII: Influence of the Oligoamine RE 1492 on the Deformability of Red Blood Cells
Author(s) -
Neumann Matthias,
Müller Susann,
Grosse Johannes,
Lerche Dietmar,
Rehse Klaus
Publication year - 1994
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19943270806
Subject(s) - membrane , red blood cell , chemistry , hemolysis , biophysics , pipette , red cell , cytosol , platelet , biochemistry , chromatography , biology , medicine , immunology , enzyme
The influence of the oligoamine RE 1492 on the deformability of R ed B lood C ells (RBCs) was measured with the micropipette aspiration technique and the capillary rigidometer. The maximal cell flow resistance (MCFR) and the apparent elastic membrane shear modulus μ were increased by 45% at RE 1492 concentrations > 10 μmol/L. There was a decrease of the surface/volume ratio of 6% at RE 1492 concentrations of 25 μmol/L. The qualitative analysis of the polypeptide pattern of membranes and extracted membranes of human RBCs suggests that the reduction of deformability is due to an increased affinity of skeletal proteins to the cytosolic part of the membrane. RE 1492 caused a decrease of osmotic hemolysis by 80% at concentrations of 8 μmol/L.