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Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XVIII: Oligoamines with Fluorescent Properties, Part B: Fluorophores in the Molecular Periphery
Author(s) -
Rehse K.,
Seidel T.
Publication year - 1994
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19943270611
Subject(s) - chemistry , macromolecule , fluorescence , quinoline , carbazole , inducer , benzene , membrane , biological activity , in vitro , platelet aggregation , biophysics , platelet , stereochemistry , biochemistry , organic chemistry , biology , physics , quantum mechanics , immunology , gene
Seventeen N,N ′‐benzene‐1,3‐dimethane and nine N,N′,N ″‐benzene‐1,3,5‐trimethane derivatives with fluorescent properties have been synthesized. Three of them show antiplatelet activities (inducer collagen, IC50 Born‐test ) in concentrations < 10 μmol/L. They are suitable for interaction studies with biological macromolecules and synthetical and biological membranes. Structure activity relationships demonstrate that heteropolycyclic fluorophores i.e. quinoline, dibenzofurane, or carbazole are favorable substituents for this purpose.