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Synthesis and Anticancer Activity of 2‐Substituted 2,3‐Dihydro‐1,3,2‐benzoxazaphosphorin‐4‐one and its 2‐Oxide Derivatives
Author(s) -
Kostka Krzysztof,
Porada Marek,
Graczyk Julita
Publication year - 1994
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19943270408
Subject(s) - chemistry , combinatorial chemistry , oxide , stereochemistry , organic chemistry
As a result of the reaction of salicylic amide with PCl 3 and POCl 3 2‐chloro‐2,3‐dihydro‐1,3,2‐benzoxazaphosphorin‐4‐one ( 1 ) and its 2‐oxide 2 are obtained. Compounds 1 and 2 form amides with amines in 2‐position. Antineoplastic action of the derivatives containing the bis(2‐chloroethyl)amide group in 2‐position was found.