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Formation of 1H ‐Aziridines from Chalcones and Hydroxylamine
Author(s) -
Kammermeier Thomas,
Kaiser Alexander,
Lee Gwan Sun,
Burgemeister Thomas,
Wiegrebe Wolfgang
Publication year - 1994
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19943270403
Subject(s) - hydroxylamine , aziridine , chemistry , oxime , molecule , medicinal chemistry , stereochemistry , organic chemistry , ring (chemistry)
Highly substituted chalcones 1 do not react with two molecules of hydroxylamine affording dioximes 2 or hydroxyamino‐oximes 3 as expected according to von Auwers ' procedure: only one molecule of hydroxylamine is consumed leading to trans ‐configurated 2‐benzoyl‐3‐phenyl‐ 1H ‐aziridines 4 .