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Antineoplastic and Antiviral Activities of Podophyllotoxin Related Lignans
Author(s) -
Gordaliza Marina,
Castro María A.,
GarcíaGrávalos María D.,
Ruiz Pilar,
Del Corral José M. Miguel,
Feliciano Arturo San
Publication year - 1994
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19943270309
Subject(s) - podophyllotoxin , vesicular stomatitis virus , baby hamster kidney cell , virology , vesicular stomatitis , herpes simplex virus , hamster , virus , leukemia , biology , kidney , pharmacology , chemistry , microbiology and biotechnology , immunology , stereochemistry , endocrinology
28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P‐388 murine leukemia, A‐549 human lung carcinoma, and HT‐29 colon carcinoma, while antiviral assays were performed on herpes simplex virus type I infecting fibroblasts of monkey kidney (HSV/CV‐1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both groups of assays at concentrations below 1μM; deoxypodophyllotoxin ( 1 ) being the most potent compound in all cases.