Premium
Synthesis and Anticonvulsant Activity of New Dibenzo[1,2]thiazepine S,S ‐Dioxides
Author(s) -
Diaz Juan A.,
Montero Enrique,
Vega Salvador,
Darias Victoriano,
Tello M. Luisa,
Abdallah Suzanne S.
Publication year - 1994
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19943270306
Subject(s) - anticonvulsant , strychnine , chemistry , stereochemistry , biological activity , epilepsy , biochemistry , in vitro , neuroscience , biology
A new series of 11‐substituted 6,11‐dihydro‐6‐methyl‐dibenzo[ c,f ]‐[1,2]thiazepine S,S ‐dioxides was synthesized. Some of the components show significant anticonvulsant activity in the MES, pentetrazol and strychnine tests. The more active compounds are devoid of neurotoxic effects.