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Synthesis of N ‐(9 H ‐Xanthen‐9‐yl)aminoalkanamide and N ‐(9 H ‐Thioxanthen‐9‐yl)aminoalkanamide Derivatives and their in vitro Evaluation as Potential Intercalators and Antitumor Drugs
Author(s) -
Filippatos Evangelos,
PapadakiValiraki Aspasia,
Todoulou Ourania,
JacqueminSablon Alain
Publication year - 1994
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19943270202
Subject(s) - chemistry , cytotoxicity , intercalation (chemistry) , stereochemistry , in vitro , thio , dna , molecule , biochemistry , organic chemistry
A series of new N ‐(9 H ‐xanthen‐9‐yl)aminoalkanamide and N ‐(9 H ‐thio‐xanthen‐9‐yl)aminoalkanamide derivatives was synthesized and evaluated as potential intercalators by measuring their DNA binding affinity. They were also tested for cytotoxic activity against L1210. The results suggest that the cytotoxicity of these molecules was not due to an intercalating mechanism.