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Synthesis of the First Phosphonoretinoic Acid Diethyl Ester
Author(s) -
Neidlein Richard,
Matuschek Bernd
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933261207
Subject(s) - trifluoroacetic acid , wittig reaction , chemistry , ylide , aldehyde , hydrolysis , organic chemistry , salt (chemistry) , catalysis
The first phosphonoretinoic acid diethyl ester 2 was prepared by Wittig reaction of the phosphonoaldehyde 4 and the ylide 6 . The aldehyde 4 was synthesized by smooth hydrolysis of the phosphonoacetal 3 with trifluoroacetic acid. The reaction of 3 with trimethylsilylbromide, hydrolysis, and precipitation resulted in salt 5 .