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Effects of Oxygen Radicals, Hydrogen Peroxide and Water‐soluble Singlet Oxygen Carriers on 5‐ and 12‐Lipoxygenase
Author(s) -
Müller Klaus,
Ziereis Klaus
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933261010
Subject(s) - hydrogen peroxide , singlet oxygen , chemistry , radical , oxygen , lipoxygenase , photochemistry , oxygene , peroxide , hydrogen , organic chemistry , enzyme
Inhibition of 5‐lipoxygenase from bovine polymorphonuclear leukocytes and 12‐lipoxygenase from bovine platelets by active oxygen species has been studied. Oxygen radicals and hydrogen peroxide markedly inhibited 12‐lipoxygenase, whereas 5‐lipoxygenase activity was only moderately influenced. Singlet oxygen liberated from water‐soluble naphthalene endoperoxides was without effect.