Cyclic Ureas, III: On the Metabolism of the Enantiomers of Cyclic Ureas in Rats | Zendy

Maurer Hans H. | Zendy; Biwersi Joachim | Zendy; Knabe Joachim | Zendy

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Cyclic Ureas, III: On the Metabolism of the Enantiomers of Cyclic Ureas in Rats

Author(s) -

Maurer Hans H.,

Biwersi Joachim,

Knabe Joachim

Publication year - 1993

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19933260908

Subject(s) - chemistry , enantiomer , metabolism , enantioselective synthesis , urine , chromatography , mass spectrometry , stereochemistry , biochemistry , catalysis

Studies are described on the metabolism of the enantiomers of 1 , 2 , and 3 in rats. The metabolites were identified in urine after cleavage of conjugates and extraction using gas chromatography‐mass spectrometry. Qualitative enantioselective differences of the metabolism of 1 , 2 , and 3 could not be detected. Because oxidation of 1 and 2 to the corresponding barbiturates could not be found and 3 was oxidized to mephenytoin only in minor amounts, this pathway is not a prerequisite for the sedative‐hypnotic effects of 1 , 2 , and 3 .

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