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Cyclic Ureas, III: On the Metabolism of the Enantiomers of Cyclic Ureas in Rats
Author(s) -
Maurer Hans H.,
Biwersi Joachim,
Knabe Joachim
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933260908
Subject(s) - chemistry , enantiomer , metabolism , enantioselective synthesis , urine , chromatography , mass spectrometry , stereochemistry , biochemistry , catalysis
Studies are described on the metabolism of the enantiomers of 1 , 2 , and 3 in rats. The metabolites were identified in urine after cleavage of conjugates and extraction using gas chromatography‐mass spectrometry. Qualitative enantioselective differences of the metabolism of 1 , 2 , and 3 could not be detected. Because oxidation of 1 and 2 to the corresponding barbiturates could not be found and 3 was oxidized to mephenytoin only in minor amounts, this pathway is not a prerequisite for the sedative‐hypnotic effects of 1 , 2 , and 3 .