Premium
Synthesis and Antimicrobial Evaluation of Novel Oxa(thia)diazolylquinolines and Oxa(thia)diazepino[7,6‐ b ] quinolines
Author(s) -
Khalil M. A.,
ElSayed O. A.,
ElShamy H. A.
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933260812
Subject(s) - chemistry , antimicrobial , quinoline , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry
Three novel series of quinoline derivatives have been prepared by cyclization of the intermediate 3[(substituted)thiocarbamoyl‐hydrazonomethyl]‐2‐chloroquinolines and 3‐aroylhydrazonomethyl‐2‐chloroquinolines: 3‐(3‐Acetyl‐5‐(substituted)‐2,3‐dihydro‐1,3, 4‐oxa(thia)diazol‐2‐yl)‐2‐chloroquinolines ( 4 ; 5 ), 3‐(5‐(subtituted)‐1,3,4‐oxa(thia)diazol‐2‐yl)‐2‐chloroquinolines ( 6 ; 7 ), and 2‐(substituted)‐1,3,4‐oxa(thia)diazepino[7,6‐ b ]quinolines ( 8 ; 9 ). The antimicrobial activity of these compounds was studied.