Synthesis and Antitumor Activity of Some New 2‐Chloroethylnitrosoureas | Zendy

Filippatos Evangelos | Zendy; PapadakiValiraki Aspasia | Zendy; Roussakis Christos | Zendy; Verbist JeanFrancois | Zendy

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Synthesis and Antitumor Activity of Some New 2‐Chloroethylnitrosoureas

Author(s) -

Filippatos Evangelos,

PapadakiValiraki Aspasia,

Roussakis Christos,

Verbist JeanFrancois

Publication year - 1993

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19933260805

Subject(s) - chemistry , epidermoid carcinoma , stereochemistry , in vitro , leukemia , nitrosourea , pharmacology , carcinoma , medicine , biochemistry , chemotherapy

The synthesis of a series of N ‐(2‐chloroethyl)‐ N ′‐(9 H ‐xanthen‐9‐yl)‐ N ‐nitrosoureas and N ‐(2‐chloroethyl)‐ N ′‐(9 H ‐thioxanthen‐9‐yl)‐ N ‐nitrosoureas is described. The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active. N ‐(2‐chloroethyl)‐ N ′‐(2‐methoxy‐9 H ‐xanthen‐9‐yl)‐ N ‐nitrosourea ( 8e ) was active against leukemia P388 tumor system in mice.

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