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Synthesis and Antitumor Activity of Some New 2‐Chloroethylnitrosoureas
Author(s) -
Filippatos Evangelos,
PapadakiValiraki Aspasia,
Roussakis Christos,
Verbist JeanFrancois
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933260805
Subject(s) - chemistry , epidermoid carcinoma , stereochemistry , in vitro , leukemia , nitrosourea , pharmacology , carcinoma , medicine , biochemistry , chemotherapy
The synthesis of a series of N ‐(2‐chloroethyl)‐ N ′‐(9 H ‐xanthen‐9‐yl)‐ N ‐nitrosoureas and N ‐(2‐chloroethyl)‐ N ′‐(9 H ‐thioxanthen‐9‐yl)‐ N ‐nitrosoureas is described. The title compounds were evaluated against NSCLCN6 L16 bronchial epidermoid carcinoma in vitro and some of them were found to be active. N ‐(2‐chloroethyl)‐ N ′‐(2‐methoxy‐9 H ‐xanthen‐9‐yl)‐ N ‐nitrosourea ( 8e ) was active against leukemia P388 tumor system in mice.