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Synthesis and Biological Activity of Bromolignans and Cyclolignans
Author(s) -
Feliciano Arturo San,
Medarde Manuel,
de Clairac Rafael Pelaez Lamamie,
López Jose Luis,
Puebla Pilar,
Gravalos M Dolores García,
Lázaro Pilar Ruiz,
de Quesada M Teresa García
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933260709
Subject(s) - podophyllotoxin , lignan , biological activity , chemistry , pharmacology , stereochemistry , biochemistry , biology , in vitro
Nine lignan derivatives ( 4 ‐ 12 ) have been obtained from (‐)‐yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P‐388, A‐549, HT‐29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows antiviral (HSV‐1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.