Premium
Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XXI: 4,4′‐Alkylene‐bis‐sydnone Imines
Author(s) -
Rehse Klaus,
Martens Antje
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933260511
Subject(s) - sydnone , chemistry , platelet aggregation , methylene , stereochemistry , ethylene , platelet , medicinal chemistry , organic chemistry , catalysis , ring (chemistry) , immunology , biology
Two methylene‐, seven ethylene‐, eleven propylene‐ and two 4,4′‐butylene‐bis‐sydnone imines have been synthesized and tested for their antiplatelet ( Born ‐test, collagen) and anticoagulant ( Quick ‐test) activity in vitro . The most active compounds were found in the ethylene and propylene series. The most favourable substituents in 3‐position of the sydnone were hexyl to octyl or phenylethyl to phenylbutyl groups. Six compounds exhibit an IC 50 ≤ 10 μmol/L against platelet aggregation. Three compounds showed an IC 75 ≤ 200 μmol/L concerning the fibrin formation (Quick Δt ≥ 7s).