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Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XX: 4,4′,4″‐(1,3,5)‐Benzene‐tris‐sydnone Imines
Author(s) -
Rehse Klaus,
Martens Antje
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933260407
Subject(s) - sydnone , chemistry , imine , tris , prodrug , platelet aggregation , derivative (finance) , stereochemistry , alkyl , antithrombotic , platelet , medicinal chemistry , organic chemistry , biochemistry , catalysis , medicine , ring (chemistry) , cardiology , economics , financial economics , immunology , biology
The synthesis of ten tris‐sydnone imine derivatives, unknown up to now, is described. All compounds are alkyl or arylalkyl substituted in 3‐position of the sydnone imine. The most powerful agent was the 3‐propyl derivative 6c . It inhibits the aggregation of human platelets induced by collagen in a concentration of 1 γmol/L half maximally. Its N ‐ethoxycarbonyl derivative 7c , which was designed as a prodrug, showed only small antithrombotic effects in rats. The reason for this low degree of activity is discussed.