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Nonsteriodal Antiinflammatory Agents, XVII: Inhibition of Bovine Cyclooxygenase and 5‐Lipoxygenase by N ‐Alkyldiphenyl‐pyrrolyl Acetic and Propionic Acid Derivatives
Author(s) -
Dannhardt G.,
Lehr M.
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933260308
Subject(s) - cyclooxygenase , lipoxygenase , chemistry , acetic acid , arachidonate 5 lipoxygenase , enzyme , enzyme inhibitor , biochemistry , stereochemistry , pharmacology , arachidonic acid , biology
Abstract A series of 19 N ‐alkyl‐diarylpyrrolyl‐acetic and ‐propionic acid derivatives was synthesized and tested. Using bovine blood as enzyme source the inhibition of cyclooxygenase and 5‐lipoxygenase, respectively, was applied to determine the antiinflammatory activity. In general all compounds tested inhibit 5‐lipoxygenase more effectively than cyclooxygenase. A structure‐activity relationship is discussed.