Nonsteriodal Antiinflammatory Agents, XVII: Inhibition of Bovine Cyclooxygenase and 5‐Lipoxygenase by  N ‐Alkyldiphenyl‐pyrrolyl Acetic and Propionic Acid Derivatives | Zendy

Dannhardt G. | Zendy; Lehr M. | Zendy

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Nonsteriodal Antiinflammatory Agents, XVII: Inhibition of Bovine Cyclooxygenase and 5‐Lipoxygenase by N ‐Alkyldiphenyl‐pyrrolyl Acetic and Propionic Acid Derivatives

Author(s) -

Dannhardt G.,

Lehr M.

Publication year - 1993

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19933260308

Subject(s) - cyclooxygenase , lipoxygenase , chemistry , acetic acid , arachidonate 5 lipoxygenase , enzyme , enzyme inhibitor , biochemistry , stereochemistry , pharmacology , arachidonic acid , biology

A series of 19 N ‐alkyl‐diarylpyrrolyl‐acetic and ‐propionic acid derivatives was synthesized and tested. Using bovine blood as enzyme source the inhibition of cyclooxygenase and 5‐lipoxygenase, respectively, was applied to determine the antiinflammatory activity. In general all compounds tested inhibit 5‐lipoxygenase more effectively than cyclooxygenase. A structure‐activity relationship is discussed.

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