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Alkaloids of Cynanchum vincetoxicum : Efficacy against MDA‐MB‐231 Mammary Carcinoma Cells
Author(s) -
Tanner Ulrike,
Wiegrebe Wolfgang
Publication year - 1993
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19933260203
Subject(s) - mammary carcinoma , chemistry , oestrogen receptor , alkaloid , carcinoma , pharmacology , biology , medicine , stereochemistry , cancer , breast cancer
Alkaloids 1 ‐ 4 from Cynanchum vincetoxicum (asclepiadaceae) (Scheme 1) do not have affinity to the oestrogen receptor but they inhibit the growth of the hormone‐independent mammary carcinoma cells MDA‐MB‐231 (Fig. 1) and bind to nucleosides and nucleotides (Table 1). Intercalation was not observed.