Premium
Determination of the Stereochemistry of Chemotherapeutics Derived from 5‐Nitrofurfural: NOE Difference Spectroscopy as a Simple and Reliable Method
Author(s) -
Holzer Wolfgang
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923251205
Subject(s) - homonuclear molecule , chemistry , nuclear magnetic resonance spectroscopy , spectroscopy , stereochemistry , substructure , nuclear overhauser effect , simple (philosophy) , significant difference , molecule , mathematics , organic chemistry , physics , philosophy , statistics , structural engineering , quantum mechanics , engineering , epistemology
Homonuclear NOE difference spectroscopy is shown to be a rapid and reliable tool for the determination of stereochemistry regarding the ‐C=N‐ substructure of 5‐nitrofurfural derivatives of type 1–10 , including several known chemotherapeutic agents. The assignments resting on the NOE difference experiments are in full agreement with those based on 13 C‐NMR data.